3BIY
Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histone acetyltransferase p300 | polymer | 380 | 43975.9 | 1 | UniProt (Q09472) Pfam (PF08214) In PDB | Homo sapiens (human) | E1A-associated protein p300 |
| 2 | A | BROMIDE ION | non-polymer | 79.9 | 5 | Chemie (BR) | |||
| 3 | A | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | non-polymer | 994.8 | 1 | Chemie (01K) | |||
| 4 | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A: 1287 - 1666 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Arg 1637 | Lys 1637 | engineered mutation |
| Gly 1652 | Met 1652 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43975.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1394.3 | |
| All* | Total formula weight | 45370.2 |
