3BIY

Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR A 1521

Chain	Residue
A	LYS1426
A	HOH1675
A	HOH1693
A	HOH1727

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 1522

Chain	Residue
A	GLN1661

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 1523

Chain	Residue
A	ASN1304

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 1524

Chain	Residue
A	HOH1829

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BR A 1525

Chain	Residue
A	SER1476
A	HOH1679
A	HOH1850
A	PRO1406
A	LYS1407

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site_id	AC6
Number of Residues	31
Details	BINDING SITE FOR RESIDUE 01K A 700

Chain	Residue
A	SER1396
A	TYR1397
A	LEU1398
A	ASP1399
A	SER1400
A	ARG1410
A	THR1411
A	TYR1414
A	TRP1436
A	CYS1438
A	PRO1440
A	TYR1446
A	LYS1456
A	ILE1457
A	PRO1458
A	ARG1462
A	TRP1466
A	TYR1467
A	HOH1672
A	HOH1681
A	HOH1694
A	HOH1696
A	HOH1713
A	HOH1716
A	HOH1760
A	HOH1767
A	HOH1775
A	HOH1780
A	HOH1817
A	HOH1820
A	HOH1885

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:24819397

Chain	Residue	Details
A	LEU1398
A	ARG1410
A	ILE1457
A	ARG1462
A	TRP1466

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17065153

Chain	Residue	Details
A	LYS1336
A	LYS1473

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546

Chain	Residue	Details
A	LYS1499

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18995842, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS1542
A	LYS1546

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546, ECO:0000269|PubMed:18995842

Chain	Residue	Details
A	LYS1549

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS1554
A	LYS1560

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS1555
A	LYS1583

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:15004546, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS1558

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