3B9F
1.6 A structure of the PCI-thrombin-heparin complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | L | Prothrombin | polymer | 49 | 5641.2 | 1 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (Human) | Coagulation factor II |
2 | H | Prothrombin | polymer | 259 | 29764.2 | 1 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (Human) | Coagulation factor II |
3 | I | Plasma serine protease inhibitor | polymer | 395 | 44529.7 | 1 | UniProt (P05154) Pfam (PF00079) UniProt (by SIFTS) (Q9N2I2) In PDB | Homo sapiens (Human) | Protein C inhibitor, Acrosomal serine protease inhibitor,Plasminogen activator inhibitor 3,PAI3,PCI,Serpin A5 |
4 | A | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
5 | B | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 595.5 | 1 | In PDB GlyTouCan (G55525GN) | |||
6 | H, I | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
7 | H, I | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
8 | water | water | 18.0 | 523 | Chemie (HOH) |
Sequence modifications
H: 16 - 247 (UniProt: P00734)
I: 17 - 387 (UniProt: P05154)
PDB | External Database | Details |
---|---|---|
Ala 195 | Ser 568 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -7 | - | expression tag |
Gly -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
Ser 5 | - | expression tag |
Ser 6 | - | expression tag |
Gly 7 | - | expression tag |
His 8 | - | expression tag |
Ile 9 | - | expression tag |
Asp 10 | - | expression tag |
Asp 11 | - | expression tag |
Asp 12 | - | expression tag |
Asp 13 | - | expression tag |
Lys 14 | - | expression tag |
His 15 | - | expression tag |
Met 16 | - | expression tag |
Asn 45 | Ser 64 | see sequence details |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 79935.1 | |
Branched | Number of molecules | 2 |
Total formula weight | 962.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 748.7 | |
All* | Total formula weight | 81646.6 |