3B9F
1.6 A structure of the PCI-thrombin-heparin complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Prothrombin | polymer | 49 | 5641.2 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (Human) | Coagulation factor II |
| 2 | B (H) | Prothrombin | polymer | 259 | 29764.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (Human) | Coagulation factor II |
| 3 | C (I) | Plasma serine protease inhibitor | polymer | 395 | 44529.7 | 1 | UniProt (P05154) Pfam (PF00079) UniProt (by SIFTS) (Q9N2I2) | Homo sapiens (Human) | Protein C inhibitor, Acrosomal serine protease inhibitor,Plasminogen activator inhibitor 3,PAI3,PCI,Serpin A5 |
| 4 | D (A) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 5 | E (B) | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 595.5 | 1 | In PDB GlyTouCan (G55525GN) | |||
| 6 | F, J, K (H, I) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | G, H, I, L, M (H, I) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 8 | N, O, P (L, H, I) | water | water | 18.0 | 523 | Chemie (HOH) |
Sequence modifications
H: 16 - 247 (UniProt: P00734)
I: 17 - 387 (UniProt: P05154)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | expression tag |
| Gly -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| His 2 | - | expression tag |
| His 3 | - | expression tag |
| His 4 | - | expression tag |
| Ser 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Gly 7 | - | expression tag |
| His 8 | - | expression tag |
| Ile 9 | - | expression tag |
| Asp 10 | - | expression tag |
| Asp 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Lys 14 | - | expression tag |
| His 15 | - | expression tag |
| Met 16 | - | expression tag |
| Asn 45 | Ser 64 | see sequence details |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 79935.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 962.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 748.7 | |
| All* | Total formula weight | 81646.6 |
