3B2R

Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	cGMP-specific 3',5'-cyclic phosphodiesterase	polymer	330	38202.0	2	UniProt (O76074) Pfam (PF00233) In PDB	Homo sapiens (Human)	CGB-PDE, cGMP-binding cGMP-specific phosphodiesterase
2	A, B	2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE	non-polymer		488.6	2	Chemie (VDN)
3		water	water		18.0	183	Chemie (HOH)

Sequence modifications

A, B: 535 - 860 (UniProt: O76074)

PDB	External Database	Details
Gly 531	-	expression tag
Ser 532	-	expression tag
His 533	-	expression tag
Met 534	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76404.0
Non-Polymers*	Number of molecules	2
	Total formula weight	977.2
All*	Total formula weight	77381.2

*Water molecules are not included.