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3B2R

Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE VDN A 1
ChainResidue
ATYR612
AHOH865
AHOH894
BGLN854
BGLU858
AHIS613
ACYS677
AILE680
AILE768
AALA779
AMET816
AGLN817
APHE820

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE VDN B 1
ChainResidue
AGLU858
AHOH976
BTYR612
BHIS613
BCYS677
BILE680
BILE768
BALA779
BMET816
BGLN817
BPHE820
BHOH867
BHOH883

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY
ChainResidueDetails
AHIS653-TYR664

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AHIS613
BHIS613

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1T9R, ECO:0007744|PDB:1T9S, ECO:0007744|PDB:1TBF
ChainResidueDetails
AHIS617
AHIS653
AASP654
AASP764
BHIS617
BHIS653
BASP654
BASP764

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149
ChainResidueDetails
AGLN817
BGLN817

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PDB entries from 2024-07-24

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