3AN2

The structure of the centromeric nucleosome containing CENP-A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone H3-like centromeric protein A	polymer	143	16305.9	2	UniProt (P49450) Pfam (PF00125) In PDB	Homo sapiens (human)	Centromere protein A, CENP-A, Centromere autoantigen A
2	B, F	Histone H4	polymer	106	11676.7	2	UniProt (B2R4R0) Pfam (PF15511) UniProt (by SIFTS) (P62805) In PDB	Homo sapiens (human)
3	C, G	Histone H2A type 1-B/E	polymer	133	14447.8	2	UniProt (P04908) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (human)	Histone H2A/m, Histone H2A/a, Histone H2A.2
4	D, H	Histone H2B type 1-J	polymer	129	14358.2	2	UniProt (P06899) Pfam (PF00125) In PDB	Homo sapiens (human)	Histone H2B.r, H2B/r, Histone H2B.1
5	I, J	147 mer DNA	polymer	147	45367.1	2

Sequence modifications

A, E: 1 - 140 (UniProt: P49450)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

B, F: 0 - 102 (UniProt: B2R4R0)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

C, G: 0 - 129 (UniProt: P04908)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

D, H: 0 - 125 (UniProt: P06899)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	204311.4
All*	Total formula weight	204311.4

*Water molecules are not included.