3ALQ
Crystal structure of TNF-TNFR2 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Tumor necrosis factor | polymer | 157 | 17279.4 | 6 | UniProt (P01375) Pfam (PF00229) | Homo sapiens (human) | TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin |
| 2 | G, H, I, J, K... (R, S, T, U, V...) | Tumor necrosis factor receptor superfamily member 1B | polymer | 173 | 18785.2 | 6 | UniProt (P20333) Pfam (PF00020) | Homo sapiens (human) | Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor-binding protein 2, TBPII, TBP-2 |
| 3 | M, N, O, P, Q... (R, S, T, U, V...) | COBALT (II) ION | non-polymer | 58.9 | 6 | Chemie (CO) | |||
| 4 | AA, S, T, U, V... (U, A, B, C, D...) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 157 (UniProt: P01375)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | Lys 87 | engineered mutation |
| Ser 65 | Lys 141 | engineered mutation |
| Pro 90 | Lys 166 | engineered mutation |
| Arg 98 | Lys 174 | engineered mutation |
| Asn 112 | Lys 188 | engineered mutation |
| Pro 128 | Lys 204 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 216387.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 353.6 | |
| All* | Total formula weight | 216741.2 |
