3ALQ

Crystal structure of TNF-TNFR2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
D	0005164	molecular_function	tumor necrosis factor receptor binding
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
E	0005164	molecular_function	tumor necrosis factor receptor binding
E	0006955	biological_process	immune response
E	0016020	cellular_component	membrane
F	0005164	molecular_function	tumor necrosis factor receptor binding
F	0006955	biological_process	immune response
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO R 2

Chain	Residue
R	HIS40
R	ASP54
R	GLU57

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO S 1

Chain	Residue
S	HIS40
S	ASP54
S	GLU57

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO T 3

Chain	Residue
T	HIS40
T	ASP54
T	GLU57

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CO U 4

Chain	Residue
U	HIS40
U	ASP54

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CO V 5

Chain	Residue
V	HIS40
V	ASP54

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO W 6

Chain	Residue
W	HIS40
W	ASP54
W	GLU57

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Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF

Chain	Residue	Details
A	LEU48-PHE64

---

site_id	PS00652
Number of Residues	36
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Crlrey.Ydqtaqm....C..Csk.Cspgqhakvf..Ctkts..DTVC

Chain	Residue	Details
R	CYS18-CYS53
R	CYS56-CYS96

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	148
Details	Repeat: {"description":"TNFR-Cys 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	246
Details	Repeat: {"description":"TNFR-Cys 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	258
Details	Repeat: {"description":"TNFR-Cys 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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