3AAF

Structure of WRN RQC domain bound to double-stranded DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Werner syndrome ATP-dependent helicase	polymer	134	15351.5	2	UniProt (Q14191) Pfam (PF09382)	Homo sapiens (human)	Werner syndrome protein, WRN
2	C, D (C, D)	DNA (5'-D(*AP*CP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*GP*T)-3')	polymer	14	4279.8	2
3	E, F (A, B)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	G, H, I, J (A, B, C, D)	water	water		18.0	338	Chemie (HOH)

Sequence modifications

A, B: 949 - 1079 (UniProt: Q14191)

PDB	External Database	Details
Gly 946	-	expression tag
Ile 947	-	expression tag
Arg 948	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	39262.7
Non-Polymers*	Number of molecules	2
	Total formula weight	118.1
All*	Total formula weight	39380.8

*Water molecules are not included.