3A9E
Crystal structure of a mixed agonist-bound RAR-alpha and antagonist-bound RXR-alpha heterodimer ligand binding domains
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 240 | 26767.9 | 1 | UniProt (P28700) Pfam (PF00104) | Mus musculus (mouse) | Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1 |
| 2 | B (B) | Retinoic acid receptor alpha | polymer | 269 | 30504.4 | 1 | UniProt (P10276) Pfam (PF00104) | Homo sapiens (human) | RAR-alpha, Nuclear receptor subfamily 1 group B member 1 |
| 3 | C (I) | 13-mer (LXXLL motif) from Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 1 | UniProt (Q15596) | HOMO SAPIENS | |
| 4 | D (A) | (2E,4E,6Z)-3-methyl-7-(5,5,8,8-tetramethyl-3-propoxy-5,6,7,8-tetrahydronaphthalen-2-yl)octa-2,4,6-trienoic acid | non-polymer | 396.6 | 1 | Chemie (754) | |||
| 5 | E (B) | RETINOIC ACID | non-polymer | 300.4 | 1 | Chemie (REA) | |||
| 6 | F, G, H (A, B, I) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 58852.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 697.0 | |
| All* | Total formula weight | 59549.2 |
