3A9E
Crystal structure of a mixed agonist-bound RAR-alpha and antagonist-bound RXR-alpha heterodimer ligand binding domains
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 240 | 26767.9 | 1 | UniProt (P28700) Pfam (PF00104) | Mus musculus (mouse) | Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1 |
| 2 | B (B) | Retinoic acid receptor alpha | polymer | 269 | 30504.4 | 1 | UniProt (P10276) Pfam (PF00104) | Homo sapiens (human) | RAR-alpha, Nuclear receptor subfamily 1 group B member 1 |
| 3 | C (I) | 13-mer (LXXLL motif) from Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 1 | UniProt (Q15596) | HOMO SAPIENS | |
| 4 | D (A) | (2E,4E,6Z)-3-methyl-7-(5,5,8,8-tetramethyl-3-propoxy-5,6,7,8-tetrahydronaphthalen-2-yl)octa-2,4,6-trienoic acid | non-polymer | 396.6 | 1 | Chemie (754) PubChem (87204847) PubChem (177352) PubChem (6442223) PubChem (12020728) | |||
| 5 | E (B) | RETINOIC ACID | non-polymer | 300.4 | 1 | Chemie (REA) PubChem (23275881) PubChem (25145416) PubChem (445925) PubChem (87179195) PubChem (87519764) PubChem (87980058) PubChem (88439848) PubChem (88525859) PubChem (88604688) PubChem (5538) PubChem (444795) PubChem (449171) PubChem (5282379) PubChem (6336207) PubChem (6336229) PubChem (6419708) PubChem (6603983) PubChem (9796370) PubChem (9861147) PubChem (10881132) PubChem (12358677) PubChem (12358678) PubChem (12358679) PubChem (12358681) PubChem (134688661) PubChem (139597075) PubChem (145826768) PubChem (166478803) | |||
| 6 | F, G, H (A, B, I) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 58852.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 697.0 | |
| All* | Total formula weight | 59549.2 |
