3A2H
Crystal structure of the rat vitamin D receptor ligand binding domain complexed with TEI-9647 and a synthetic peptide containing the NR2 box of DRIP 205
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D3 receptor | polymer | 265 | 30055.5 | 1 | UniProt (P13053) Pfam (PF00104) | Rattus norvegicus (Rat) | VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1 |
| 2 | B (B) | Mediator of RNA polymerase II transcription subunit 1 peptide | polymer | 13 | 1570.9 | 1 | UniProt (Q15648) | Homo sapiens | DRIP 205 NR2 box peptide, Mediator complex subunit 1, Peroxisome proliferator-activated receptor-binding protein, Vitamin D receptor-interacting protein complex component DRIP205, Activator-recruited cofactor 205 kDa component |
| 3 | C (A) | (1S,3R,5Z,7E,20S,23S)-1,3-dihydroxy-23,26-epoxy-9,10-secocholesta-5,7,10,25(27)-tetraen-26-one | non-polymer | 426.6 | 1 | Chemie (TEJ) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A: 116 - 164 (UniProt: P13053)
A: 212 - 423 (UniProt: P13053)
| PDB | External Database | Details |
|---|---|---|
| Gly 112 | - | expression tag |
| Ser 113 | - | expression tag |
| His 114 | - | expression tag |
| Met 115 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31626.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 426.6 | |
| All* | Total formula weight | 32053.0 |
