3A2H

Crystal structure of the rat vitamin D receptor ligand binding domain complexed with TEI-9647 and a synthetic peptide containing the NR2 box of DRIP 205

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Vitamin D3 receptor	polymer	265	30055.5	1	UniProt (P13053) Pfam (PF00104) In PDB	Rattus norvegicus (Rat)	VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1
2	B	Mediator of RNA polymerase II transcription subunit 1 peptide	polymer	13	1570.9	1	UniProt (Q15648) In PDB	Homo sapiens	DRIP 205 NR2 box peptide, Mediator complex subunit 1, Peroxisome proliferator-activated receptor-binding protein, Vitamin D receptor-interacting protein complex component DRIP205, Activator-recruited cofactor 205 kDa component
3	A	(1S,3R,5Z,7E,20S,23S)-1,3-dihydroxy-23,26-epoxy-9,10-secocholesta-5,7,10,25(27)-tetraen-26-one	non-polymer		426.6	1	Chemie (TEJ)
4		water	water		18.0	46	Chemie (HOH)

Sequence modifications

A: 116 - 164 (UniProt: P13053)

PDB	External Database	Details
Gly 112	-	expression tag
Ser 113	-	expression tag
His 114	-	expression tag
Met 115	-	expression tag

A: 212 - 423 (UniProt: P13053)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31626.4
Non-Polymers*	Number of molecules	1
	Total formula weight	426.6
All*	Total formula weight	32053.0

*Water molecules are not included.