3A2H
Crystal structure of the rat vitamin D receptor ligand binding domain complexed with TEI-9647 and a synthetic peptide containing the NR2 box of DRIP 205
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D3 receptor | polymer | 265 | 30055.5 | 1 | UniProt (P13053) Pfam (PF00104) | Rattus norvegicus (Rat) | VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1 |
| 2 | B (B) | Mediator of RNA polymerase II transcription subunit 1 peptide | polymer | 13 | 1570.9 | 1 | UniProt (Q15648) | Homo sapiens | DRIP 205 NR2 box peptide, Mediator complex subunit 1, Peroxisome proliferator-activated receptor-binding protein, Vitamin D receptor-interacting protein complex component DRIP205, Activator-recruited cofactor 205 kDa component |
| 3 | C (A) | (1S,3R,5Z,7E,20S,23S)-1,3-dihydroxy-23,26-epoxy-9,10-secocholesta-5,7,10,25(27)-tetraen-26-one | non-polymer | 426.6 | 1 | Chemie (TEJ) PubChem (45479714) PubChem (91025155) PubChem (100997207) PubChem (75021430) PubChem (15481883) PubChem (146156139) PubChem (100997206) PubChem (9547692) PubChem (9547693) PubChem (9888727) PubChem (10274073) PubChem (156963156) PubChem (15481882) PubChem (164887609) PubChem (166639120) PubChem (171154195) PubChem (172897942) PubChem (172913514) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A: 116 - 164 (UniProt: P13053)
A: 212 - 423 (UniProt: P13053)
| PDB | External Database | Details |
|---|---|---|
| Gly 112 | - | expression tag |
| Ser 113 | - | expression tag |
| His 114 | - | expression tag |
| Met 115 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31626.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 426.6 | |
| All* | Total formula weight | 32053.0 |
