32TH

Crystal structure of YTHDF2 in complex with compound 20 (ZA801)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	YTH domain-containing family protein 2	polymer	167	19367.8	1	UniProt (Q9Y5A9)	Homo sapiens (human)	CLL-associated antigen KW-14,High-glucose-regulated protein 8,Renal carcinoma antigen NY-REN-2
2	B (A)	methyl 4-(6-cyclopropyl-4-oxidanylidene-pyrazolo[3,4-b]pyridin-3-yl)benzoate	non-polymer		309.3	1	Chemie (A1KFC)
3	C, D, E (A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL) PubChem (753)
4	F, G (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG) PubChem (8117)
5	H (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6	I (A)	water	water		18.0	120	Chemie (HOH)

Sequence modifications

A: 408 - 552 (UniProt: Q9Y5A9)

PDB	External Database	Details
Met 386	-	initiating methionine
Gly 387	-	expression tag
Ser 388	-	expression tag
Ser 389	-	expression tag
Tyr 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag
Ser 397	-	expression tag
Ser 398	-	expression tag
Gly 399	-	expression tag
Glu 400	-	expression tag
Asn 401	-	expression tag
Leu 402	-	expression tag
Tyr 403	-	expression tag
Phe 404	-	expression tag
Gln 405	-	expression tag
His 406	-	expression tag
Met 407	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19367.8
Non-Polymers*	Number of molecules	7
	Total formula weight	893.9
All*	Total formula weight	20261.8

*Water molecules are not included.