2ZPX
TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Tumor necrosis factor | polymer | 157 | 17283.4 | 3 | UniProt (P01375) Pfam (PF00229) | Homo sapiens (Human) | TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, Antagonistic TNF mutant (R1antTNF-T8) |
| 2 | D, E (A, C) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 157 (UniProt: P01375)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | Lys 87 | engineered mutation |
| Ser 65 | Lys 141 | engineered mutation |
| Thr 84 | Ala 160 | engineered mutation |
| Pro 85 | Val 161 | engineered mutation |
| Ala 86 | Ser 162 | engineered mutation |
| Ile 87 | Tyr 163 | engineered mutation |
| Asn 88 | Gln 164 | engineered mutation |
| Arg 89 | Thr 165 | engineered mutation |
| Pro 90 | Lys 166 | engineered mutation |
| Arg 98 | Lys 174 | engineered mutation |
| Asn 112 | Lys 188 | engineered mutation |
| Pro 128 | Lys 204 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 51850.3 | |
| All* | Total formula weight | 51850.3 |
