2ZNU
Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, neodysiherbaine A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor, ionotropic kainate 1 | polymer | 256 | 29093.4 | 1 | UniProt (P39086) Pfam (PF10613) Pfam (PF00060) | Homo sapiens (Human) | Glutamate receptor 5, GluR-5, GluR5, Excitatory amino acid receptor 3, EAA3, GluR5 ligand-binding core |
| 2 | B (A) | (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid | non-polymer | 291.3 | 1 | Chemie (NDZ) | |||
| 3 | C, D, E, F (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 4 | Chemie (BME) | |||
| 4 | G (A) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 415 - 529 (UniProt: P39086)
A: 652 - 790 (UniProt: P39086)
A: 652 - 790 (UniProt: P39086)
| PDB | External Database | Details |
|---|---|---|
| Gly 600 | - | linker |
| Thr 601 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29093.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 603.8 | |
| All* | Total formula weight | 29697.2 |
