2ZNU

Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, neodysiherbaine A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NDZ A 1

Chain	Residue
A	GLU426
A	MET722
A	GLU723
A	SER726
A	TYR749
A	HOH797
A	TYR474
A	PRO501
A	THR503
A	ARG508
A	GLY673
A	SER674
A	THR675
A	SER706

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BME A 791

Chain	Residue
A	GLU427
A	ASP707
A	ILE710
A	MET722
A	SER726
A	TYR729
A	HOH829
A	HOH838
A	HOH988

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 2

Chain	Residue
A	PRO517
A	GLN771
A	LEU776
A	HOH868

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME A 3

Chain	Residue
A	ASN442
A	TYR464

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME A 4

Chain	Residue
A	ILE504
A	TYR506
A	GLU509
A	HOH973
A	HOH974

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:21893069, ECO:0007744|PDB:2ZNS, ECO:0007744|PDB:3FUZ

Chain	Residue	Details
A	PRO501
A	THR503
A	ARG508
A	SER674
A	THR675
A	GLU723

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000255

Chain	Residue	Details
A	SER695

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000255

Chain	Residue	Details
A	THR731

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN416
A	ASN736

---