2ZKN
X-ray structure of mutant galectin-1/lactose complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Galectin-1 | polymer | 134 | 14503.1 | 2 | UniProt (P09382) Pfam (PF00337) | Homo sapiens (Human) | Lectin galactoside-binding soluble 1, Beta-galactoside-binding lectin L-14-I, Lactose-binding lectin 1, S-Lac lectin 1, Galaptin, 14 kDa lectin, HPL, HBL, Putative MAPK-activating protein PM12 |
| 2 | C (C) | beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900004) GlyTouCan (G84224TW) | beta-lactose | ||
| 3 | D, E (A, B) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 134 (UniProt: P09382)
| PDB | External Database | Details |
|---|---|---|
| Ser 2 | Cys 3 | engineered mutation |
| Ser 16 | Cys 17 | engineered mutation |
| Ser 42 | Cys 43 | engineered mutation |
| Ser 60 | Cys 61 | engineered mutation |
| Ser 88 | Cys 89 | engineered mutation |
| Ser 130 | Cys 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29006.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| All* | Total formula weight | 29348.5 |
