2ZI4

C4S dCK variant of dCK in complex with L-dA+ADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Deoxycytidine kinase	polymer	279	32572.5	1	UniProt (P27707) Pfam (PF01712)	Homo sapiens (human)	dCK
2	B (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3	C (A)	(2S,3R,5S)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol	non-polymer		251.2	1	Chemie (3L1)
4	D (A)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
5	E (A)	water	water		18.0	86	Chemie (HOH)

Sequence modifications

A: 1 - 260 (UniProt: P27707)

PDB	External Database	Details
Met -18	-	expression tag
Gly -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ser 9	Cys 9	engineered mutation
Ser 45	Cys 45	engineered mutation
Ser 59	Cys 59	engineered mutation
Ser 146	Cys 146	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32572.5
Non-Polymers*	Number of molecules	3
	Total formula weight	702.7
All*	Total formula weight	33275.3

*Water molecules are not included.