2ZGJ
Crystal Structure of D86N-GzmM Complexed with Its Optimal Synthesized Substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Granzyme M | polymer | 240 | 26131.6 | 1 | UniProt (P51124) Pfam (PF00089) | Homo sapiens (human) | Met-ase, Natural killer cell granular protease, HU-Met-1, Met-1 serine protease |
| 2 | B (B) | SSGKVPLS | polymer | 8 | 774.9 | 1 | |||
| 3 | C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 1 - 232 (UniProt: P51124)
| PDB | External Database | Details |
|---|---|---|
| Asn 86 | Asp 111 | engineered mutation |
| Leu 233 | - | expression tag |
| Glu 234 | - | expression tag |
| His 235 | - | expression tag |
| His 236 | - | expression tag |
| His 237 | - | expression tag |
| His 238 | - | expression tag |
| His 239 | - | expression tag |
| His 240 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26906.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 384.3 | |
| All* | Total formula weight | 27290.7 |
