2ZDX
Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Pyruvate dehydrogenase kinase isozyme 4 | polymer | 394 | 44771.0 | 2 | UniProt (Q16654) Pfam (PF10436) Pfam (PF02518) | Homo sapiens (Human) | Pyruvate dehydrogenase kinase isoform 4 |
| 2 | C, D (A, B) | 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol | non-polymer | 296.3 | 2 | Chemie (P4A) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B: 20 - 411 (UniProt: Q16654)
| PDB | External Database | Details |
|---|---|---|
| Gly 18 | - | expression tag |
| Pro 19 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 89542.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 592.6 | |
| All* | Total formula weight | 90134.6 |
