2ZDX

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006885	biological_process	regulation of pH
A	0008286	biological_process	insulin receptor signaling pathway
A	0009267	biological_process	cellular response to starvation
A	0010510	biological_process	regulation of acetyl-CoA biosynthetic process from pyruvate
A	0010565	biological_process	regulation of ketone metabolic process
A	0010906	biological_process	regulation of glucose metabolic process
A	0016301	molecular_function	kinase activity
A	0042304	biological_process	regulation of fatty acid biosynthetic process
A	0042593	biological_process	glucose homeostasis
A	0042594	biological_process	response to starvation
A	0045124	biological_process	regulation of bone resorption
A	0046320	biological_process	regulation of fatty acid oxidation
A	0071398	biological_process	cellular response to fatty acid
A	0072593	biological_process	reactive oxygen species metabolic process
A	2000811	biological_process	negative regulation of anoikis
B	0004672	molecular_function	protein kinase activity
B	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006885	biological_process	regulation of pH
B	0008286	biological_process	insulin receptor signaling pathway
B	0009267	biological_process	cellular response to starvation
B	0010510	biological_process	regulation of acetyl-CoA biosynthetic process from pyruvate
B	0010565	biological_process	regulation of ketone metabolic process
B	0010906	biological_process	regulation of glucose metabolic process
B	0016301	molecular_function	kinase activity
B	0042304	biological_process	regulation of fatty acid biosynthetic process
B	0042593	biological_process	glucose homeostasis
B	0042594	biological_process	response to starvation
B	0045124	biological_process	regulation of bone resorption
B	0046320	biological_process	regulation of fatty acid oxidation
B	0071398	biological_process	cellular response to fatty acid
B	0072593	biological_process	reactive oxygen species metabolic process
B	2000811	biological_process	negative regulation of anoikis

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE P4A A 500

Chain	Residue
A	LEU255
A	THR358
A	HOH501
A	HOH511
A	ASN258
A	ALA262
A	ASP293
A	GLY295
A	GLY297
A	VAL298
A	LEU306
A	PHE330

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE P4A B1500

Chain	Residue
B	LEU255
B	ASN258
B	ALA262
B	ASP293
B	GLY295
B	GLY297
B	VAL298
B	LEU306
B	LEU350
B	THR358
B	HOH1501
B	HOH1503

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:18658136

Chain	Residue	Details
A	GLU254
A	ASP293
A	SER312
A	GLY329
B	GLU254
B	ASP293
B	SER312
B	GLY329

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site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Interaction with the other subunit in the homodimer

Chain	Residue	Details
A	TYR157
A	ARG161
A	TRP395
B	TYR157
B	ARG161
B	TRP395

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1jm6

Chain	Residue	Details
A	GLU254
A	HIS250

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1jm6

Chain	Residue	Details
B	GLU254
B	HIS250

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