2Z5T

Molecular basis for the inhibition of p53 by Mdmx

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (M, N, O)	Mdm4 protein	polymer	140	15661.6	3	UniProt (Q4V944) Pfam (PF02201) UniProt (by SIFTS) (Q7ZUW7)	Danio rerio (Zebrafish)	Zebrafish MDMX with L46V and V95L mutations
2	B, D, F (P, Q, R)	Cellular tumor antigen p53	polymer	15	1808.0	3	UniProt (P04637) Pfam (PF08563)		Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13
3	G, H, I, J, K... (M, P, N, Q, O...)	water	water		18.0	355	Chemie (HOH)

Sequence modifications

M, N, O: 15 - 140 (UniProt: Q4V944)

PDB	External Database	Details
Met 1	-	expression tag
Ala 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
Asp 9	-	expression tag
Asp 10	-	expression tag
Asp 11	-	expression tag
Asp 12	-	expression tag
Lys 13	-	expression tag
Ile 14	-	expression tag
Val 46	Leu 46	engineered mutation
Leu 95	Val 95	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	52408.8
All*	Total formula weight	52408.8

*Water molecules are not included.