2Z5T

Molecular basis for the inhibition of p53 by Mdmx

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0005634	cellular_component	nucleus
M	0043066	biological_process	negative regulation of apoptotic process
M	0051726	biological_process	regulation of cell cycle
N	0005634	cellular_component	nucleus
N	0043066	biological_process	negative regulation of apoptotic process
N	0051726	biological_process	regulation of cell cycle
O	0005634	cellular_component	nucleus
O	0043066	biological_process	negative regulation of apoptotic process
O	0051726	biological_process	regulation of cell cycle

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17967874, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:28842590

Chain	Residue	Details
P	SER15
Q	SER15
R	SER15

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphothreonine; by CK1, VRK1 and VRK2 => ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:31527692

Chain	Residue	Details
P	THR18
Q	THR18
R	THR18

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine; by CHEK2, CK1 and PLK3 => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:20041275

Chain	Residue	Details
P	SER20
Q	SER20
R	SER20

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21597459

Chain	Residue	Details
P	LYS24
Q	LYS24
R	LYS24

---