2Z2P
Crystal Structure of catalytically inactive H270A virginiamycin B lyase from Staphylococcus aureus with Quinupristin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Virginiamycin B lyase | polymer | 299 | 33034.2 | 2 | UniProt (P17978) | Staphylococcus aureus | Streptogramin B lyase |
| 2 | C, D (C, D) | Quinupristin | polymer | 8 | 1024.2 | 2 | BIRD (PRD_000505) | STREPTOMYCES GRAMINOFACIEN | |
| 3 | E, F, H, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | G, J (A, B) | 5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE | non-polymer | 690.8 | 2 | Chemie (DOL) PubChem (5366) PubChem (21943991) PubChem (21943994) PubChem (22525348) PubChem (60554) PubChem (470125) PubChem (57098016) PubChem (57459918) PubChem (5496903) PubChem (72734290) PubChem (6323289) PubChem (91589610) PubChem (73896910) PubChem (5353985) PubChem (6435782) PubChem (122129995) PubChem (10212112) PubChem (129520962) PubChem (124201618) PubChem (137965482) PubChem (132285205) PubChem (133562652) PubChem (137553216) PubChem (137699109) PubChem (168010521) PubChem (172878422) PubChem (163337878) PubChem (170922447) PubChem (170923030) PubChem (172878206) PubChem (172885177) |
Sequence modifications
A, B: 1 - 299 (UniProt: P17978)
| PDB | External Database | Details |
|---|---|---|
| Glu 51 | Pro 51 | conflict |
| Asn 54 | Thr 54 | conflict |
| Lys 55 | Pro 55 | conflict |
| Gly 56 | Asp 56 | conflict |
| Thr 211 | Pro 211 | conflict |
| Ser 212 | Leu 212 | conflict |
| Ala 267 | Gly 267 | conflict |
| Ala 270 | His 270 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 68117.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1478.9 | |
| All* | Total formula weight | 69595.9 |
