2Z2P
Crystal Structure of catalytically inactive H270A virginiamycin B lyase from Staphylococcus aureus with Quinupristin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Virginiamycin B lyase | polymer | 299 | 33034.2 | 2 | UniProt (P17978) | Staphylococcus aureus | Streptogramin B lyase |
| 2 | C, D (C, D) | Quinupristin | polymer | 8 | 1024.2 | 2 | BIRD (PRD_000505) | STREPTOMYCES GRAMINOFACIEN | |
| 3 | E, F, H, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G, J (A, B) | 5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE | non-polymer | 690.8 | 2 | Chemie (DOL) |
Sequence modifications
A, B: 1 - 299 (UniProt: P17978)
| PDB | External Database | Details |
|---|---|---|
| Glu 51 | Pro 51 | conflict |
| Asn 54 | Thr 54 | conflict |
| Lys 55 | Pro 55 | conflict |
| Gly 56 | Asp 56 | conflict |
| Thr 211 | Pro 211 | conflict |
| Ser 212 | Leu 212 | conflict |
| Ala 267 | Gly 267 | conflict |
| Ala 270 | His 270 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 68117.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1478.9 | |
| All* | Total formula weight | 69595.9 |
