2YOJ
HCV NS5B polymerase complexed with pyridonylindole compound
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | RNA-DIRECTED RNA POLYMERASE | polymer | 585 | 65319.8 | 2 | UniProt (O92972) Pfam (PF00998) In PDB | HEPATITIS C VIRUS | NS5B, P68 |
2 | A, B | 4-fluoranyl-6-[(7-fluoranyl-4-oxidanylidene-3H-quinazolin-6-yl)methyl]-8-(2-oxidanylidene-1H-pyridin-3-yl)furo[2,3-e]indole-7-carboxylic acid | non-polymer | 488.4 | 2 | Chemie (8Y6) | |||
3 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
4 | water | water | 18.0 | 1573 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: O92972)
PDB | External Database | Details |
---|---|---|
Glu 571 | - | expression tag |
Asn 572 | - | expression tag |
Leu 573 | - | expression tag |
Tyr 574 | - | expression tag |
Phe 575 | - | expression tag |
Gln 576 | - | expression tag |
Gly 577 | - | expression tag |
Leu 578 | - | expression tag |
Glu 579 | - | expression tag |
His 580 | - | expression tag |
His 581 | - | expression tag |
His 582 | - | expression tag |
His 583 | - | expression tag |
His 584 | - | expression tag |
His 585 | - | expression tag |
Gly 440 | Glu 2859 | conflict |
Ile 520 | Thr 2939 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 130639.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1356.7 | |
All* | Total formula weight | 131996.3 |