2YOJ

HCV NS5B polymerase complexed with pyridonylindole compound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	RNA-DIRECTED RNA POLYMERASE	polymer	585	65319.8	2	UniProt (O92972) Pfam (PF00998)	HEPATITIS C VIRUS	NS5B, P68
2	C, F (A, B)	4-fluoranyl-6-[(7-fluoranyl-4-oxidanylidene-3H-quinazolin-6-yl)methyl]-8-(2-oxidanylidene-1H-pyridin-3-yl)furo[2,3-e]indole-7-carboxylic acid	non-polymer		488.4	2	Chemie (8Y6)
3	D, E, G, H (A, B)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
4	I, J (A, B)	water	water		18.0	1573	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: O92972)

PDB	External Database	Details
Glu 571	-	expression tag
Asn 572	-	expression tag
Leu 573	-	expression tag
Tyr 574	-	expression tag
Phe 575	-	expression tag
Gln 576	-	expression tag
Gly 577	-	expression tag
Leu 578	-	expression tag
Glu 579	-	expression tag
His 580	-	expression tag
His 581	-	expression tag
His 582	-	expression tag
His 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
Gly 440	Glu 2859	conflict
Ile 520	Thr 2939	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	130639.6
Non-Polymers*	Number of molecules	6
	Total formula weight	1356.7
All*	Total formula weight	131996.3

*Water molecules are not included.