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2YOJ

HCV NS5B polymerase complexed with pyridonylindole compound

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE 8Y6 A 1569
ChainResidue
AARG200
AILE447
ATYR448
APO41570
AHOH2617
AHOH2679
AHOH2705
AHOH2739
AHOH2854
AHOH2856
AHOH2867
AASN316
ACYS366
ASER367
AGLY410
AASN411
AMET414
ATYR415
AGLN446

site_idAC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE 8Y6 B 1564
ChainResidue
BARG200
BASN316
BCYS366
BSER367
BLEU384
BGLY410
BASN411
BMET414
BTYR415
BGLN446
BILE447
BTYR448
BPO41565
BHOH2513
BHOH2517
BHOH2580
BHOH2624
BHOH2688
BHOH2690

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 A 1570
ChainResidue
ASER367
AARG386
A8Y61569
AHOH2409
AHOH2684
AHOH2688

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PO4 A 1571
ChainResidue
AARG505
AVAL530
AARG531
ATHR532
AHOH2799
AHOH2800
AHOH2833
AHOH2870
AHOH2871
AHOH2872

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 B 1565
ChainResidue
BSER367
BARG386
B8Y61564
BHOH2337
BHOH2583
BHOH2586
BHOH2691

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PO4 B 1566
ChainResidue
APRO22
AARG401
AHOH2083
AHOH2086
BARG114
BHOH2259
BHOH2692
BHOH2693

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-10-30

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