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2YM8

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ASERINE/THREONINE-PROTEIN KINASE CHK1polymer28933043.01UniProt (O14757)
Pfam (PF00069)
In PDB
HOMO SAPIENS (HUMAN)CHECKPOINT KINASE 1
2A(R)-5-(8-CHLOROISOQUINOLIN-3-YLAMINO)-3-(1-(DIMETHYLAMINO)PROPAN-2-YLOXY)PYRAZINE-2-CARBONITRILEnon-polymer382.81Chemie (YM8)
3A1,2-ETHANEDIOLnon-polymer62.19Chemie (EDO)
4waterwater18.0121Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight33043.0
Non-Polymers*Number of molecules10
Total formula weight941.5
All*Total formula weight33984.4
*Water molecules are not included.

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PDB entries from 2024-04-24

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