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2YM8

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE YM8 A 1271
ChainResidue
AALA36
ASER147
AASP148
AHOH2054
ALYS38
ALEU84
AGLU85
ATYR86
ACYS87
AGLU134
AASN135
ALEU137

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO A 1272
ChainResidue
AHIS112
AASN266

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1273
ChainResidue
AARG129
ALEU164
AASN165
ALYS166

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1274
ChainResidue
AGLY123
AARG156
ATYR157
AASN158
AASN159

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1275
ChainResidue
AGLN108
ALYS267
APRO268
ALEU269

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 1276
ChainResidue
ATRP221
ALYS224
AHIS243

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 1277
ChainResidue
AARG29
AARG181
AASN249

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1278
ChainResidue
AGLU32
AVAL247
AGLU248
AASN249
AALA252

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1279
ChainResidue
ALYS132
AGLU134
AHOH2120
AHOH2121

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 1280
ChainResidue
AALA116
ALYS260
ATYR265

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAYGEVQlAvnrvteea..........VAVK
ChainResidueDetails
ALEU15-LYS38

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ItHrDIKpeNLLL
ChainResidueDetails
AILE126-LEU138

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP130

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU15
ALYS38

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER280

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER286

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32357935
ChainResidueDetails
ALYS132

225158

PDB entries from 2024-09-18

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