2Y9Q
Crystal structure of human ERK2 complexed with a MAPK docking peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MITOGEN-ACTIVATED PROTEIN KINASE 1 | polymer | 362 | 41588.8 | 1 | UniProt (P28482) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | MAP KINASE 1, MAPK 1, ERT1, EXTRACELLULAR SIGNAL-REGULATED KINASE 2, ERK-2, MAP KINASE ISOFORM P42, P42-MAPK, MITOGEN-ACTIVATED PROTEIN KINASE 2, MAP KINASE 2, MAPK 2, ERK2 |
| 2 | B (B) | MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1 | polymer | 18 | 2044.5 | 1 | UniProt (Q9BUB5) | HOMO SAPIENS | MAP KINASE SIGNAL-INTEGRATING KINASE 1, MNK1 |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 546 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: P28482)
B: 434 - 451 (UniProt: Q9BUB5)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 440 | Cys 440 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43633.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 506.2 | |
| All* | Total formula weight | 44139.5 |
