2Y7Q
THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA | polymer | 188 | 21722.1 | 1 | UniProt (P12319) Pfam (PF13927) Pfam (PF13895) In PDB | HOMO SAPIENS (HUMAN) | HIGH AFFINITY IGE RECEPTOR FC EPSILON RI, IGE FC RECEPTOR SUBUNIT ALPHA, FC-EPSILON RI-ALPHA, FCERI |
2 | B, D | IG EPSILON CHAIN C REGION | polymer | 327 | 36354.8 | 2 | UniProt (P01854) Pfam (PF07654) In PDB | HOMO SAPIENS (HUMAN) | |
3 | C | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
4 | A, B, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A: 1 - 176 (UniProt: P12319)
B, D: 224 - 547 (UniProt: P01854)
PDB | External Database | Details |
---|---|---|
Glu -2 | - | cloning artifact |
Thr -1 | - | cloning artifact |
Gly 0 | - | cloning artifact |
Ala 74 | Asn 99 | engineered mutation |
Ala 135 | Asn 160 | engineered mutation |
Ala 142 | Thr 167 | engineered mutation |
Ala 143 | Val 168 | cloning artifact |
Gly 177 | - | cloning artifact |
Thr 178 | - | cloning artifact |
Lys 179 | - | cloning artifact |
His 180 | - | expression tag |
His 181 | - | expression tag |
His 182 | - | expression tag |
His 183 | - | expression tag |
His 184 | - | expression tag |
His 185 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 222 | - | expression tag |
Ile 223 | - | expression tag |
Ala 225 | Cys 105 | engineered mutation |
Gln 265 | Asn 146 | engineered mutation |
Gln 371 | Asn 252 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 94431.7 | |
Branched | Number of molecules | 1 |
Total formula weight | 748.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.6 | |
All* | Total formula weight | 95844.0 |