2Y5L
orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | FRUCTOSE-1,6-BISPHOSPHATASE 1 | polymer | 338 | 36859.4 | 8 | UniProt (P09467) Pfam (PF00316) Pfam (PF18913) | HOMO SAPIENS (HUMAN) | FBPASE 1,D-FRUCTOSE-1,6-BISPHOSPHATE 1-PHOSPHOHYDROLASE 1 |
| 2 | I, J, K, L, M... (A, B, C, D, E...) | N-{[(2Z)-5-bromo-1,3-thiazol-2(3H)-ylidene]carbamoyl}-3-chlorobenzenesulfonamide | non-polymer | 396.7 | 8 | Chemie (RO8) | |||
| 3 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 534 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 0 - 337 (UniProt: P09467)
| PDB | External Database | Details |
|---|---|---|
| Lys 217 | Arg 218 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 294875.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3173.3 | |
| All* | Total formula weight | 298048.7 |
