2Y42

Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with NADH and Mn

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	3-ISOPROPYLMALATE DEHYDROGENASE	polymer	359	38398.9	4	UniProt (Q5SIY4) Pfam (PF00180)	THERMUS THERMOPHILUS	ISOPROPYLMALATE DEHYDROGENASE, 3-IPM-DH, BETA-IPM DEHYDROGENASE, IMDH, IPMDH
2	E, H, K, L, O (A, B, C, D)	BICINE	non-polymer		163.2	5	Chemie (BCN)
3	F, I, M, P (A, B, C, D)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
4	G, J, N, Q (A, B, C, D)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
5	R, S, T, U (A, B, C, D)	water	water		18.0	241	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 345 (UniProt: Q5SIY4)

PDB	External Database	Details
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Ala 346	-	expression tag
Ala 347	-	expression tag
Ala 348	-	expression tag
Leu 349	-	expression tag
Glu 350	-	expression tag
His 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag
His 355	-	expression tag
His 356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153595.5
Non-Polymers*	Number of molecules	13
	Total formula weight	3689.3
All*	Total formula weight	157284.8

*Water molecules are not included.