2Y42
Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with NADH and Mn
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0009098 | biological_process | L-leucine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051287 | molecular_function | NAD binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0009098 | biological_process | L-leucine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0051287 | molecular_function | NAD binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0009098 | biological_process | L-leucine biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0051287 | molecular_function | NAD binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0009098 | biological_process | L-leucine biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE BCN A 501 |
Chain | Residue |
A | ARG104 |
A | ASP241 |
A | ASP245 |
A | MN999 |
B | ASP217 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE NAD A 900 |
Chain | Residue |
A | HIS273 |
A | GLY274 |
A | SER275 |
A | ALA276 |
A | ASP278 |
A | ASN286 |
A | HOH2042 |
A | GLU87 |
A | LEU90 |
A | LEU254 |
A | VAL272 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN A 999 |
Chain | Residue |
A | ASP241 |
A | ASP245 |
A | BCN501 |
B | ASP217 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE BCN B 501 |
Chain | Residue |
A | ASP217 |
A | MET221 |
B | ARG104 |
B | ASP241 |
B | ASP245 |
B | MN999 |
site_id | AC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE NAD B 900 |
Chain | Residue |
B | ILE11 |
B | VAL72 |
B | GLY73 |
B | GLY74 |
B | ASP78 |
B | GLY255 |
B | HIS273 |
B | GLY274 |
B | SER275 |
B | ALA276 |
B | ASP278 |
B | ILE279 |
B | ASN286 |
B | HOH2044 |
B | HOH2061 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN B 999 |
Chain | Residue |
A | ASP217 |
B | ASP241 |
B | ASP245 |
B | BCN501 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE BCN B 1502 |
Chain | Residue |
A | ARG225 |
B | VAL249 |
B | GLY252 |
B | SER253 |
B | LEU254 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE BCN C 501 |
Chain | Residue |
C | ARG104 |
C | ASP241 |
C | ASP245 |
C | MN999 |
D | ASP217 |
site_id | AC9 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE NAD C 900 |
Chain | Residue |
C | VAL72 |
C | GLY73 |
C | GLY74 |
C | ASP78 |
C | LEU90 |
C | LEU254 |
C | VAL272 |
C | HIS273 |
C | GLY274 |
C | SER275 |
C | ALA276 |
C | ASP278 |
C | ILE279 |
C | ALA285 |
C | ASN286 |
C | HOH2024 |
C | HOH2074 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN C 999 |
Chain | Residue |
C | ASP241 |
C | ASP245 |
C | BCN501 |
D | ASP217 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE BCN D 501 |
Chain | Residue |
C | ASP217 |
D | ASP241 |
D | ASP245 |
D | MN999 |
site_id | BC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE NAD D 900 |
Chain | Residue |
D | ILE11 |
D | VAL72 |
D | ASP78 |
D | GLU87 |
D | HIS273 |
D | GLY274 |
D | SER275 |
D | ALA276 |
D | ASP278 |
D | ILE279 |
D | ASN286 |
D | HOH2058 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN D 999 |
Chain | Residue |
C | ASP217 |
D | ASP241 |
D | ASP245 |
D | BCN501 |
Functional Information from PROSITE/UniProt
site_id | PS00470 |
Number of Residues | 20 |
Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NIFGDIlSDlaSvlp.GSLGL |
Chain | Residue | Details |
A | ASN237-LEU256 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:7881901 |
Chain | Residue | Details |
A | GLY74 | |
A | GLY274 | |
B | GLY74 | |
B | GLY274 | |
C | GLY74 | |
C | GLY274 | |
D | GLY74 | |
D | GLY274 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ARG94 | |
B | ASP217 | |
B | ASP241 | |
B | ASP245 | |
C | ARG94 | |
C | ARG104 | |
C | ARG132 | |
C | ASP217 | |
C | ASP241 | |
C | ASP245 | |
D | ARG94 | |
A | ARG104 | |
D | ARG104 | |
D | ARG132 | |
D | ASP217 | |
D | ASP241 | |
D | ASP245 | |
A | ARG132 | |
A | ASP217 | |
A | ASP241 | |
A | ASP245 | |
B | ARG94 | |
B | ARG104 | |
B | ARG132 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | SITE: Important for catalysis |
Chain | Residue | Details |
A | TYR139 | |
B | TYR139 | |
C | TYR139 | |
D | TYR139 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | SITE: Important for catalysis => ECO:0000250 |
Chain | Residue | Details |
A | LYS185 | |
B | LYS185 | |
C | LYS185 | |
D | LYS185 |