2Y1L
Caspase-8 in Complex with DARPin-8.4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Caspase-8 subunit p18 | polymer | 159 | 18027.6 | 2 | UniProt (Q14790) Pfam (PF00656) | Homo sapiens (human) | |
| 2 | B, D (B, D) | Caspase-8 | polymer | 104 | 12036.6 | 2 | UniProt (Q14790) Pfam (PF00656) | Homo sapiens (human) | CASP-8,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,ICE-like apoptotic protease 5,MORT1-associated ced-3 homolog,MACH |
| 3 | E, F (E, F) | DARPIN-8.4 | polymer | 169 | 18216.5 | 2 | SYNTHETIC CONSTRUCT | ||
| 4 | G (H) | AC-IETD-CHO | polymer | 4 | 476.5 | 1 | SYNTHETIC CONSTRUCT | ||
| 5 | H (I) | N-(2-oxoethyl)-L-isoleucyl-L-alpha-glutamyl-N-[(1R)-2-carboxy-1-formylethyl]-L-threoninamide | polymer | 5 | 488.5 | 1 | BIRD (PRD_000301) | ||
| 6 | I, K, L (A, B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | J, M, N, O, P (B, C, E, F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 8 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 685 | Chemie (HOH) |
Sequence modifications
A, C: 217 - 374 (UniProt: Q14790)
| PDB | External Database | Details |
|---|---|---|
| Met 216 | - | initiating methionine |
| Gly 217 | Ser 217 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 97526.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 598.5 | |
| All* | Total formula weight | 98124.8 |
