2Y1E

X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with manganese.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE	polymer	398	41701.0	2	UniProt (A2VLK3)	MYCOBACTERIUM TUBERCULOSIS	DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE HAMAP, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE
2	C, G (A, B)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	D, E, F, H (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	I, J (A, B)	water	water		18.0	563	Chemie (HOH)

Sequence modifications

A, B: 1 - 389 (UniProt: A2VLK3)

PDB	External Database	Details
Thr -8	-	expression tag
Met -7	-	expression tag
Ala -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83401.9
Non-Polymers*	Number of molecules	6
	Total formula weight	494.1
All*	Total formula weight	83896.1

*Water molecules are not included.