2Y1E

X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with manganese.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008299	biological_process	isoprenoid biosynthetic process
A	0030604	molecular_function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A	0046872	molecular_function	metal ion binding
A	0070402	molecular_function	NADPH binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0030604	molecular_function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B	0046872	molecular_function	metal ion binding
B	0070402	molecular_function	NADPH binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1390

Chain	Residue
A	ASP151
A	GLU153
A	GLU222
A	HOH2249
A	HOH2250
A	HOH2251

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1391

Chain	Residue
A	ASN218
A	LYS219
A	HOH2135
A	HOH2250
A	HOH2252
A	HOH2253
A	ALA176
A	SER177
A	SER213

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1392

Chain	Residue
A	THR21
A	GLY47
A	GLY48
A	ALA49
A	HIS50
A	HOH2005
A	HOH2254
A	HOH2255
A	HOH2256

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1393

Chain	Residue
A	ARG162
A	TRP277
A	PRO278
A	HOH2125
A	HOH2257

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 1390

Chain	Residue
B	ASP151
B	GLU153
B	GLU222
B	HOH2301
B	HOH2302
B	HOH2303

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 1391

Chain	Residue
B	ALA176
B	SER177
B	SER213
B	ASN218
B	LYS219
B	HOH2303
B	HOH2304
B	HOH2305
B	HOH2306

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