2Y1E
X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with manganese.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070402 | molecular_function | NADPH binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 1390 |
| Chain | Residue |
| A | ASP151 |
| A | GLU153 |
| A | GLU222 |
| A | HOH2249 |
| A | HOH2250 |
| A | HOH2251 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1391 |
| Chain | Residue |
| A | ASN218 |
| A | LYS219 |
| A | HOH2135 |
| A | HOH2250 |
| A | HOH2252 |
| A | HOH2253 |
| A | ALA176 |
| A | SER177 |
| A | SER213 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1392 |
| Chain | Residue |
| A | THR21 |
| A | GLY47 |
| A | GLY48 |
| A | ALA49 |
| A | HIS50 |
| A | HOH2005 |
| A | HOH2254 |
| A | HOH2255 |
| A | HOH2256 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1393 |
| Chain | Residue |
| A | ARG162 |
| A | TRP277 |
| A | PRO278 |
| A | HOH2125 |
| A | HOH2257 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 1390 |
| Chain | Residue |
| B | ASP151 |
| B | GLU153 |
| B | GLU222 |
| B | HOH2301 |
| B | HOH2302 |
| B | HOH2303 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1391 |
| Chain | Residue |
| B | ALA176 |
| B | SER177 |
| B | SER213 |
| B | ASN218 |
| B | LYS219 |
| B | HOH2303 |
| B | HOH2304 |
| B | HOH2305 |
| B | HOH2306 |
