2Y1D
X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted fosmidomycin analogue and manganese.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | polymer | 398 | 41701.0 | 2 | UniProt (A2VLK3) In PDB | MYCOBACTERIUM TUBERCULOSIS | DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE HAMAP, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE |
2 | A | (1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC ACID | non-polymer | 328.1 | 1 | Chemie (34F) | |||
3 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
4 | water | water | 18.0 | 347 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 389 (UniProt: A2VLK3)
PDB | External Database | Details |
---|---|---|
Thr -8 | - | expression tag |
Met -7 | - | expression tag |
Ala -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 83401.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 438.0 | |
All* | Total formula weight | 83839.9 |