2Y1D
X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted fosmidomycin analogue and manganese.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0070402 | molecular_function | NADPH binding |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 34F A 1390 |
Chain | Residue |
A | ASP151 |
A | SER245 |
A | PRO265 |
A | MN1391 |
A | HOH2118 |
A | SER152 |
A | GLU153 |
A | ALA176 |
A | SER177 |
A | SER213 |
A | ASN218 |
A | LYS219 |
A | GLU222 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN A 1391 |
Chain | Residue |
A | ASP151 |
A | GLU153 |
A | GLU222 |
A | 34F1390 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN B 1390 |
Chain | Residue |
B | ASP151 |
B | GLU153 |
B | GLU222 |
B | HOH2227 |
B | HOH2228 |
B | HOH2229 |