2Y05
Crystal structure of human leukotriene B4 12-hydroxydehydrogenase in complex with NADP and raloxifene
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | PROSTAGLANDIN REDUCTASE 1 | polymer | 328 | 35757.5 | 4 | UniProt (Q14914) Pfam (PF16884) Pfam (PF00107) | HOMO SAPIENS (HUMAN) | 15-OXOPROSTAGLANDIN 13-REDUCTASE, NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE, PRG-1, LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE |
| 2 | E, L, Q, V (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 3 | F, G (A) | RALOXIFENE | non-polymer | 473.6 | 2 | Chemie (RAL) PubChem (5035) | |||
| 4 | H, K, M, N, U (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) PubChem (312) | |||
| 5 | I, J, O, P, R... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 6 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 438 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 4 - 329 (UniProt: Q14914)
| PDB | External Database | Details |
|---|---|---|
| Ser 2 | - | expression tag |
| Met 3 | - | expression tag |
| Ser 27 | Ala 27 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 143030.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4656.7 | |
| All* | Total formula weight | 147686.7 |
