2XYO

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	TETX2	polymer	399	45353.2	4	UniProt (Q93L51) Pfam (PF01494)	BACTEROIDES THETAIOTAOMICRON
2	E, H, L, O (A, B, C, D)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	4	Chemie (FAD)
3	F, G, I, J, M... (A, B, C, D)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
4	K (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)

Sequence modifications

A, B, C, D: 11 - 388 (UniProt: Q93L51)

PDB	External Database	Details
Ser -10	-	expression tag
Mse -9	-	expression tag
Gly -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 1	-	expression tag
Ser 2	-	expression tag
Gly 3	-	expression tag
Leu 4	-	expression tag
Val 5	-	expression tag
Pro 6	-	expression tag
Arg 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag
His 10	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	181412.8
Non-Polymers*	Number of molecules	13
	Total formula weight	4002.8
All*	Total formula weight	185415.6

*Water molecules are not included.