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2XYO

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004497molecular_functionmonooxygenase activity
A0005737cellular_componentcytoplasm
A0046677biological_processresponse to antibiotic
A0071949molecular_functionFAD binding
B0000166molecular_functionnucleotide binding
B0004497molecular_functionmonooxygenase activity
B0005737cellular_componentcytoplasm
B0046677biological_processresponse to antibiotic
B0071949molecular_functionFAD binding
C0000166molecular_functionnucleotide binding
C0004497molecular_functionmonooxygenase activity
C0005737cellular_componentcytoplasm
C0046677biological_processresponse to antibiotic
C0071949molecular_functionFAD binding
D0000166molecular_functionnucleotide binding
D0004497molecular_functionmonooxygenase activity
D0005737cellular_componentcytoplasm
D0046677biological_processresponse to antibiotic
D0071949molecular_functionFAD binding
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE FAD A 1384
ChainResidue
AILE22
AARG117
AARG121
AARG137
ALYS138
ALEU139
AASN168
AGLY169
AGLN192
ALEU287
AGLY310
AGLY23
AASP311
APRO318
AGLY321
AGLN322
AGLY323
AVAL324
AGLY25
APRO26
AVAL27
ATYR45
AGLU46
AARG47
AASP48

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 1385
ChainResidue
AARG137
ALYS156

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1386
ChainResidue
AGLY286
ALEU287
AALA288
AARG290

site_idAC4
Number of Residues23
DetailsBINDING SITE FOR RESIDUE FAD B 1384
ChainResidue
BGLY23
BGLY25
BPRO26
BVAL27
BTYR45
BGLU46
BARG47
BASP48
BARG117
BARG121
BARG137
BLEU139
BASN168
BGLY169
BGLN192
BLEU287
BGLY310
BASP311
BPRO318
BGLY321
BGLN322
BGLY323
BVAL324

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B 1385
ChainResidue
BARG137
BLYS156

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 1386
ChainResidue
BLEU287
BALA288
BARG290

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 1387
ChainResidue
BGLY75
BLEU76
BLEU77
BGLN78
BTHR79

site_idAC8
Number of Residues25
DetailsBINDING SITE FOR RESIDUE FAD C 1384
ChainResidue
CGLY23
CGLY25
CPRO26
CVAL27
CGLY28
CTYR45
CGLU46
CARG47
CASP48
CARG117
CARG121
CARG137
CLYS138
CLEU139
CALA167
CASN168
CGLY169
CGLN192
CGLY310
CASP311
CPRO318
CGLY321
CGLN322
CGLY323
CVAL324

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 C 1385
ChainResidue
CARG137
CLYS156

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 C 1386
ChainResidue
CPHE189
CLEU287
CALA288
CARG290

site_idBC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE FAD D 1384
ChainResidue
DTYR45
DGLU46
DARG47
DASP48
DLEU60
DARG117
DARG137
DLYS138
DLEU139
DALA167
DASN168
DGLY169
DGLN192
DGLY310
DASP311
DPRO318
DGLY321
DGLN322
DGLY323
DVAL324
DGLY23
DGLY25
DPRO26
DVAL27

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 D 1385
ChainResidue
DARG137
DLYS156

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 1386
ChainResidue
DPHE189
DLEU287
DALA288
DARG290

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:21590745, ECO:0007744|PDB:2XDO, ECO:0007744|PDB:2XYO, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3P9U, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99, ECO:0007744|PDB:4GUV
ChainResidueDetails
DPRO26
DTYR45
DLEU139
DGLY321
APRO26
ATYR45
ALEU139
AGLY321
BPRO26
BTYR45
BLEU139
BGLY321
CPRO26
CTYR45
CLEU139
CGLY321

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0000305|PubMed:21402075
ChainResidueDetails
AARG54
BARG54
CARG54
DARG54

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0007744|PDB:3V3O
ChainResidueDetails
AASP61
BASP61
CASP61
DASP61

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00845, ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:21590745, ECO:0007744|PDB:2XDO, ECO:0007744|PDB:2XYO, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3P9U, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99, ECO:0007744|PDB:4GUV
ChainResidueDetails
AARG117
AASP311
BARG117
BASP311
CARG117
CASP311
DARG117
DASP311

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:23999299, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3V3N, ECO:0007744|PDB:4A99
ChainResidueDetails
AGLN192
BGLN192
CGLN192
DGLN192

site_idSWS_FT_FI6
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:21402075, ECO:0000269|PubMed:23999299, ECO:0007744|PDB:2Y6Q, ECO:0007744|PDB:2Y6R, ECO:0007744|PDB:3V3O, ECO:0007744|PDB:4A6N, ECO:0007744|PDB:4A99
ChainResidueDetails
AARG213
BARG213
CARG213
DARG213

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PDB entries from 2024-06-12

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