2XXB
Penta-mutant of Thermus thermophilus lactate dehydrogenase, complex with AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | L-LACTATE DEHYDROGENASE | polymer | 310 | 32599.4 | 2 | UniProt (Q5SJA1) Pfam (PF00056) Pfam (PF02866) | THERMUS THERMOPHILUS | L-LDH |
| 2 | C, D (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 293 | Chemie (HOH) |
Sequence modifications
A, B: 22 - 331 (UniProt: Q5SJA1)
| PDB | External Database | Details |
|---|---|---|
| Trp 79 | Arg 58 | engineered mutation |
| Ala 151 | Arg 128 | engineered mutation |
| Ala 279 | Glu 260 | engineered mutation |
| Ala 299 | Glu 279 | engineered mutation |
| Ala 313 | Glu 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65198.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 694.4 | |
| All* | Total formula weight | 65893.2 |
