2XRP
Human Doublecortin N-DC Repeat (1MJD) and Mammalian Tubulin (1JFF and 3HKE) Docked into the 8-Angstrom Cryo-EM Map of Doublecortin- Stabilised Microtubules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | TUBULIN BETA-2B CHAIN | polymer | 445 | 49907.8 | 4 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) | BOS TAURUS (CATTLE) | TUBULIN BETA CHAIN |
| 2 | B, D, F, H (B, D, F, H) | TUBULIN ALPHA-1D CHAIN | polymer | 452 | 50236.4 | 4 | UniProt (Q2HJ86) Pfam (PF00091) Pfam (PF03953) | BOS TAURUS (CATTLE) | TUBULIN ALPHA CHAIN |
| 3 | I (I) | NEURONAL MIGRATION PROTEIN DOUBLECORTIN | polymer | 95 | 11029.4 | 1 | UniProt (O43602) Pfam (PF03607) | HOMO SAPIENS (HUMAN) | DOUBLECORTIN, LISSENCEPHALIN-X, LIS-X, DOUBLIN |
| 4 | J, L, N, P (A, C, E, G) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 5 | K, M, O, Q (B, D, F, H) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) |
Sequence modifications
A, C, E, G: 1 - 455 (UniProt: Q6B856)
B, D, F, H: 1 - 449 (UniProt: Q2HJ86)
| PDB | External Database | Details |
|---|---|---|
| Val 172 | Met 170 | conflict |
| Val 318 | Ile 316 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 7 | Val 7 | conflict |
| Ile 114 | Leu 114 | conflict |
| Ser 136 | Leu 136 | conflict |
| Glu 358 | Gln 358 | conflict |
| Val 437 | Met 437 | conflict |
| Glu 450 | Asp 450 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 411605.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3865.5 | |
| All* | Total formula weight | 415471.4 |
