2XRP
Human Doublecortin N-DC Repeat (1MJD) and Mammalian Tubulin (1JFF and 3HKE) Docked into the 8-Angstrom Cryo-EM Map of Doublecortin- Stabilised Microtubules
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000226 | biological_process | microtubule cytoskeleton organization |
A | 0000278 | biological_process | mitotic cell cycle |
A | 0003924 | molecular_function | GTPase activity |
A | 0005200 | molecular_function | structural constituent of cytoskeleton |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005856 | cellular_component | cytoskeleton |
A | 0005874 | cellular_component | microtubule |
A | 0007017 | biological_process | microtubule-based process |
A | 0007399 | biological_process | nervous system development |
A | 0015630 | cellular_component | microtubule cytoskeleton |
A | 0046872 | molecular_function | metal ion binding |
A | 0046982 | molecular_function | protein heterodimerization activity |
A | 1902669 | biological_process | positive regulation of axon guidance |
B | 0000226 | biological_process | microtubule cytoskeleton organization |
B | 0000278 | biological_process | mitotic cell cycle |
B | 0005200 | molecular_function | structural constituent of cytoskeleton |
B | 0005525 | molecular_function | GTP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005856 | cellular_component | cytoskeleton |
B | 0005874 | cellular_component | microtubule |
B | 0007017 | biological_process | microtubule-based process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0046872 | molecular_function | metal ion binding |
C | 0000226 | biological_process | microtubule cytoskeleton organization |
C | 0000278 | biological_process | mitotic cell cycle |
C | 0003924 | molecular_function | GTPase activity |
C | 0005200 | molecular_function | structural constituent of cytoskeleton |
C | 0005525 | molecular_function | GTP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005856 | cellular_component | cytoskeleton |
C | 0005874 | cellular_component | microtubule |
C | 0007017 | biological_process | microtubule-based process |
C | 0007399 | biological_process | nervous system development |
C | 0015630 | cellular_component | microtubule cytoskeleton |
C | 0046872 | molecular_function | metal ion binding |
C | 0046982 | molecular_function | protein heterodimerization activity |
C | 1902669 | biological_process | positive regulation of axon guidance |
D | 0000226 | biological_process | microtubule cytoskeleton organization |
D | 0000278 | biological_process | mitotic cell cycle |
D | 0005200 | molecular_function | structural constituent of cytoskeleton |
D | 0005525 | molecular_function | GTP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005856 | cellular_component | cytoskeleton |
D | 0005874 | cellular_component | microtubule |
D | 0007017 | biological_process | microtubule-based process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0046872 | molecular_function | metal ion binding |
E | 0000226 | biological_process | microtubule cytoskeleton organization |
E | 0000278 | biological_process | mitotic cell cycle |
E | 0003924 | molecular_function | GTPase activity |
E | 0005200 | molecular_function | structural constituent of cytoskeleton |
E | 0005525 | molecular_function | GTP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0005856 | cellular_component | cytoskeleton |
E | 0005874 | cellular_component | microtubule |
E | 0007017 | biological_process | microtubule-based process |
E | 0007399 | biological_process | nervous system development |
E | 0015630 | cellular_component | microtubule cytoskeleton |
E | 0046872 | molecular_function | metal ion binding |
E | 0046982 | molecular_function | protein heterodimerization activity |
E | 1902669 | biological_process | positive regulation of axon guidance |
F | 0000226 | biological_process | microtubule cytoskeleton organization |
F | 0000278 | biological_process | mitotic cell cycle |
F | 0005200 | molecular_function | structural constituent of cytoskeleton |
F | 0005525 | molecular_function | GTP binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0005856 | cellular_component | cytoskeleton |
F | 0005874 | cellular_component | microtubule |
F | 0007017 | biological_process | microtubule-based process |
F | 0016787 | molecular_function | hydrolase activity |
F | 0046872 | molecular_function | metal ion binding |
G | 0000226 | biological_process | microtubule cytoskeleton organization |
G | 0000278 | biological_process | mitotic cell cycle |
G | 0003924 | molecular_function | GTPase activity |
G | 0005200 | molecular_function | structural constituent of cytoskeleton |
G | 0005525 | molecular_function | GTP binding |
G | 0005737 | cellular_component | cytoplasm |
G | 0005856 | cellular_component | cytoskeleton |
G | 0005874 | cellular_component | microtubule |
G | 0007017 | biological_process | microtubule-based process |
G | 0007399 | biological_process | nervous system development |
G | 0015630 | cellular_component | microtubule cytoskeleton |
G | 0046872 | molecular_function | metal ion binding |
G | 0046982 | molecular_function | protein heterodimerization activity |
G | 1902669 | biological_process | positive regulation of axon guidance |
H | 0000226 | biological_process | microtubule cytoskeleton organization |
H | 0000278 | biological_process | mitotic cell cycle |
H | 0005200 | molecular_function | structural constituent of cytoskeleton |
H | 0005525 | molecular_function | GTP binding |
H | 0005737 | cellular_component | cytoplasm |
H | 0005856 | cellular_component | cytoskeleton |
H | 0005874 | cellular_component | microtubule |
H | 0007017 | biological_process | microtubule-based process |
H | 0016787 | molecular_function | hydrolase activity |
H | 0046872 | molecular_function | metal ion binding |
I | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GDP A 600 |
Chain | Residue |
A | GLY10 |
A | ASP179 |
A | ASN206 |
A | TYR224 |
A | ASN228 |
A | GLN11 |
A | CYS12 |
A | GLN15 |
A | SER140 |
A | GLY142 |
A | GLY144 |
A | THR145 |
A | GLY146 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE GTP B 500 |
Chain | Residue |
A | LEU248 |
A | LYS254 |
B | GLY10 |
B | GLN11 |
B | ALA12 |
B | GLN15 |
B | ALA99 |
B | ALA100 |
B | ASN101 |
B | SER140 |
B | GLY143 |
B | GLY144 |
B | THR145 |
B | GLY146 |
B | ILE171 |
B | GLU183 |
B | ASN206 |
B | TYR224 |
B | ASN228 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GDP C 600 |
Chain | Residue |
C | GLY10 |
C | GLN11 |
C | CYS12 |
C | GLN15 |
C | SER140 |
C | GLY142 |
C | GLY144 |
C | THR145 |
C | GLY146 |
C | ASP179 |
C | ASN206 |
C | TYR224 |
C | ASN228 |
site_id | AC4 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE GTP D 500 |
Chain | Residue |
C | LEU248 |
C | LYS254 |
D | GLY10 |
D | GLN11 |
D | ALA12 |
D | GLN15 |
D | ALA99 |
D | ALA100 |
D | ASN101 |
D | SER140 |
D | GLY143 |
D | GLY144 |
D | THR145 |
D | GLY146 |
D | ILE171 |
D | GLU183 |
D | ASN206 |
D | TYR224 |
D | ASN228 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GDP E 600 |
Chain | Residue |
E | GLY10 |
E | GLN11 |
E | CYS12 |
E | GLN15 |
E | SER140 |
E | GLY142 |
E | GLY144 |
E | THR145 |
E | GLY146 |
E | ASP179 |
E | ASN206 |
E | TYR224 |
E | ASN228 |
site_id | AC6 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE GTP F 500 |
Chain | Residue |
E | LEU248 |
E | LYS254 |
F | GLY10 |
F | GLN11 |
F | ALA12 |
F | GLN15 |
F | ALA99 |
F | ALA100 |
F | ASN101 |
F | SER140 |
F | GLY143 |
F | GLY144 |
F | THR145 |
F | GLY146 |
F | ILE171 |
F | GLU183 |
F | ASN206 |
F | TYR224 |
F | ASN228 |
site_id | AC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GDP G 600 |
Chain | Residue |
G | GLN15 |
G | SER140 |
G | GLY142 |
G | GLY144 |
G | THR145 |
G | GLY146 |
G | ASP179 |
G | ASN206 |
G | TYR224 |
G | ASN228 |
G | GLY10 |
G | GLN11 |
G | CYS12 |
site_id | AC8 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GTP H 500 |
Chain | Residue |
G | LEU248 |
H | GLY10 |
H | GLN11 |
H | ALA12 |
H | GLN15 |
H | ALA99 |
H | ALA100 |
H | ASN101 |
H | SER140 |
H | GLY143 |
H | GLY144 |
H | THR145 |
H | GLY146 |
H | ILE171 |
H | GLU183 |
H | ASN206 |
H | TYR224 |
H | ASN228 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by MARK1 and PKA => ECO:0000250|UniProtKB:Q9ESI7 |
Chain | Residue | Details |
I | SER47 | |
C | GLY144 | |
C | THR145 | |
C | GLY146 | |
C | ASN206 | |
C | ASN228 | |
E | GLN11 | |
E | SER140 | |
E | GLY144 | |
E | THR145 | |
E | GLY146 | |
D | GLU254 | |
E | ASN206 | |
E | ASN228 | |
G | GLN11 | |
G | SER140 | |
G | GLY144 | |
G | THR145 | |
G | GLY146 | |
G | ASN206 | |
G | ASN228 | |
F | GLU254 | |
H | GLU254 | |
A | GLY146 | |
A | ASN206 | |
A | ASN228 | |
C | GLN11 | |
C | SER140 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by ABL => ECO:0000255 |
Chain | Residue | Details |
I | TYR70 | |
D | GLU71 | |
D | SER140 | |
D | GLY144 | |
D | THR145 | |
D | THR179 | |
D | ASN206 | |
D | ASN228 | |
F | GLN11 | |
F | GLU71 | |
F | SER140 | |
B | GLU71 | |
F | GLY144 | |
F | THR145 | |
F | THR179 | |
F | ASN206 | |
F | ASN228 | |
H | GLN11 | |
H | GLU71 | |
H | SER140 | |
H | GLY144 | |
H | THR145 | |
B | SER140 | |
H | THR179 | |
H | ASN206 | |
H | ASN228 | |
B | GLY144 | |
B | THR145 | |
B | THR179 | |
B | ASN206 | |
B | ASN228 | |
D | GLN11 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by PKC => ECO:0000255 |
Chain | Residue | Details |
I | SER74 | |
I | SER110 | |
F | TYR452 | |
H | TYR452 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000255 |
Chain | Residue | Details |
I | SER90 | |
D | LYS40 | |
F | LYS40 | |
H | LYS40 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CK2, MARK1 and PKA => ECO:0000250|UniProtKB:Q9ESI7 |
Chain | Residue | Details |
I | SER115 | |
D | TYR282 | |
F | TYR282 | |
H | TYR282 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68373 |
Chain | Residue | Details |
B | SER439 | |
D | SER439 | |
F | SER439 | |
H | SER439 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68369 |
Chain | Residue | Details |
B | GLU446 | |
D | GLU446 | |
F | GLU446 | |
H | GLU446 | |
E | THR287 | |
E | THR292 | |
G | THR287 | |
G | THR292 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q71U36 |
Chain | Residue | Details |
B | TYR452 | |
D | TYR452 | |
F | TYR452 | |
H | TYR452 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0 |
Chain | Residue | Details |
A | GLU448 | |
C | GLU448 | |
E | GLU448 | |
G | GLU448 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
A | LYS60 | |
C | LYS60 | |
E | LYS60 | |
G | LYS60 |
site_id | SWS_FT_FI11 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
A | LYS326 | |
C | LYS326 | |
E | LYS326 | |
G | LYS326 |