2XR5
Crystal structure of the complex of the carbohydrate recognition domain of human DC-SIGN with pseudo dimannoside mimic.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CD209 ANTIGEN | polymer | 166 | 19032.0 | 1 | UniProt (Q9NNX6) Pfam (PF00059) | HOMO SAPIENS (HUMAN) | DC-SIGN, DENDRITIC CELL-SPECIFIC ICAM-3-GRABBING NON-INTEGRIN 1, DC-SIGN1, C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER L, CD209, MDC-SIGN1A TYPE I |
| 2 | B (A) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) | |||
| 3 | C (A) | dimethyl (1S,2S,4S,5S)-4,5-dihydroxycyclohexane-1,2-dicarboxylate | non-polymer | 232.2 | 1 | Chemie (07B) | |||
| 4 | D (A) | ETHANOLAMINE | non-polymer | 61.1 | 1 | Chemie (ETA) | |||
| 5 | E, F, G (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 6 | H, I, J (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 7 | K (A) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A: 254 - 404 (UniProt: Q9NNX6)
| PDB | External Database | Details |
|---|---|---|
| Met 239 | - | expression tag |
| Ala 240 | - | expression tag |
| Ser 241 | - | expression tag |
| Trp 242 | - | expression tag |
| Ser 243 | - | expression tag |
| His 244 | - | expression tag |
| Pro 245 | - | expression tag |
| Gln 246 | - | expression tag |
| Phe 247 | - | expression tag |
| Glu 248 | - | expression tag |
| Lys 249 | - | expression tag |
| Ile 250 | - | expression tag |
| Glu 251 | - | expression tag |
| Gly 252 | - | expression tag |
| Arg 253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19032.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 700.1 | |
| All* | Total formula weight | 19732.0 |
