2XN9
Crystal structure of the ternary complex between human T cell receptor, staphylococcal enterotoxin H and human major histocompatibility complex class II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | T CELL RECEPTOR ALPHA CHAIN C REGION | polymer | 204 | 22313.8 | 1 | UniProt (P01848) Pfam (PF09291) | HOMO SAPIENS (HUMAN) | |
| 2 | B (B) | T CELL RECEPTOR BETA-1 CHAIN C REGION | polymer | 244 | 27785.8 | 1 | UniProt (P01850) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | |
| 3 | C (C) | ENTEROTOXIN H | polymer | 217 | 25180.2 | 1 | UniProt (P0A0M0) Pfam (PF01123) Pfam (PF02876) | STAPHYLOCOCCUS AUREUS | SEH, STAPHYLOCOCCAL ENTEROTOXIN H |
| 4 | D (D) | HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, | polymer | 182 | 21155.9 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II ALPHA, MHC CLASS II ANTIGEN DRA CHAIN |
| 5 | E (E) | MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II BETA CHAIN | polymer | 190 | 22080.7 | 1 | UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | HOMO SAPIENS (HUMAN) | MHC CLASS II ANTIGEN DRB1.1, DR-1, DR1 |
| 6 | F (F) | HEMAGGLUTININ | polymer | 13 | 1506.8 | 1 | UniProt (A8CDU0) UniProt (by SIFTS) (Q03909) | INFLUENZA A VIRUS | INFLUENZA HEMAGGLUTININ PEPTIDE |
| 7 | G, H, I, J (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 8 | K (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | L, M, N, O, P... (A, B, C, D, E...) | water | water | 18.0 | 280 | Chemie (HOH) |
Sequence modifications
A: 1 - 109 (PDB: 2XN9)
A: 110 - 204 (UniProt: P01848)
B: 1 - 114 (PDB: 2XN9)
B: 115 - 244 (UniProt: P01850)
A: 110 - 204 (UniProt: P01848)
| PDB | External Database | Details |
|---|---|---|
| Cys 158 | Thr 49 | engineered mutation |
B: 115 - 244 (UniProt: P01850)
| PDB | External Database | Details |
|---|---|---|
| Lys 118 | Asn 4 | conflict |
| Asn 119 | Lys 5 | conflict |
| Tyr 151 | Phe 37 | conflict |
| Cys 171 | Ser 57 | engineered mutation |
| Ser 189 | Cys 75 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 120023.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 391.4 | |
| All* | Total formula weight | 120414.6 |
