2XN7
Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein (T405-CF)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYROXINE-BINDING GLOBULIN | polymer | 350 | 39145.9 | 1 | UniProt (P05543) Pfam (PF00079) | HOMO SAPIENS (HUMAN) | T4-BINDING GLOBULIN, SERPIN A7 |
| 2 | B (B) | THYROXINE-BINDING GLOBULIN | polymer | 35 | 4026.8 | 1 | UniProt (P05543) | HOMO SAPIENS (HUMAN) | T4-BINDING GLOBULIN, SERPIN A7 |
| 3 | C (A) | 3,5,3',5'-TETRAIODO-L-THYRONINE | non-polymer | 776.9 | 1 | Chemie (T44) | |||
| 4 | D (A) | 3',6'-DIHYDROXY-3-OXO-3H-SPIRO[2-BENZOFURAN-1,9'-XANTHENE]-5-CARBOXYLIC ACID | non-polymer | 376.3 | 1 | Chemie (F6Z) | |||
| 5 | E, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | H, I (A, B) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A: 12 - 361 (UniProt: P05543)
| PDB | External Database | Details |
|---|---|---|
| Gly 346 | Ala 366 | engineered mutation |
| Ala 347 | Val 367 | engineered mutation |
| Met 348 | Pro 368 | engineered mutation |
| Phe 349 | Glu 369 | engineered mutation |
| Leu 350 | Val 370 | engineered mutation |
| Glu 351 | Glu 371 | engineered mutation |
| Ala 352 | Leu 372 | engineered mutation |
| Ile 353 | Ser 373 | engineered mutation |
| Pro 354 | Asp 374 | engineered mutation |
| Arg 355 | Gln 375 | engineered mutation |
| Ser 356 | Pro 376 | engineered mutation |
| Ile 357 | Glu 377 | engineered mutation |
| Pro 358 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43172.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1317.4 | |
| All* | Total formula weight | 44490.1 |
