2XN7

Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein (T405-CF)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005615	cellular_component	extracellular space

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE T44 A 1355

Chain	Residue
A	GLN238
A	LEU246
A	LEU269
A	ASN273
A	F6Z1356
B	LEU376
B	ARG378
B	ARG381

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE F6Z A 1356

Chain	Residue
A	GLU105
A	TYR225
A	GLN238
A	ASP240
A	LYS278
A	T441355
B	ARG378
A	LYS104

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1357

Chain	Residue
A	CA1358

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 1396

Chain	Residue
A	HIS226
B	HOH2019
B	HOH2021
B	HOH2023

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 1358

Chain	Residue
A	GLU200
A	ASP201
A	EDO1357

---

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. IQIDRSFMLlI

Chain	Residue	Details
B	ILE365-ILE375

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16938877","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; in variant Gary","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---