2XN3

Crystal structure of thyroxine-binding globulin complexed with mefenamic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	THYROXINE-BINDING GLOBULIN	polymer	343	38399.1	1	UniProt (P05543) Pfam (PF00079) In PDB	HOMO SAPIENS (HUMAN)	T4-BINDING GLOBULIN, SERPIN A7
2	B	THYROXINE-BINDING GLOBULIN	polymer	40	4605.4	1	UniProt (P05543) In PDB	HOMO SAPIENS (HUMAN)	T4-BINDING GLOBULIN, SERPIN A7
3	A	2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID	non-polymer		241.3	1	Chemie (ID8)
4		water	water		18.0	130	Chemie (HOH)

Sequence modifications

A: 13 - 355 (UniProt: P05543)

PDB	External Database	Details
Gly 346	Ala 366	engineered mutation
Ala 347	Val 367	engineered mutation
Met 348	Pro 368	engineered mutation
Phe 349	Glu 369	engineered mutation
Leu 350	Val 370	engineered mutation
Ala 352	Leu 372	engineered mutation
Ile 353	Ser 373	engineered mutation
Pro 354	Asp 374	engineered mutation
Arg 355	Gln 375	engineered mutation

B: 357 - 395 (UniProt: P05543)

PDB	External Database	Details
Ser 356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43004.5
Non-Polymers*	Number of molecules	1
	Total formula weight	241.3
All*	Total formula weight	43245.7

*Water molecules are not included.