2XN3
Crystal structure of thyroxine-binding globulin complexed with mefenamic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THYROXINE-BINDING GLOBULIN | polymer | 343 | 38399.1 | 1 | UniProt (P05543) Pfam (PF00079) | HOMO SAPIENS (HUMAN) | T4-BINDING GLOBULIN, SERPIN A7 |
| 2 | B (B) | THYROXINE-BINDING GLOBULIN | polymer | 40 | 4605.4 | 1 | UniProt (P05543) | HOMO SAPIENS (HUMAN) | T4-BINDING GLOBULIN, SERPIN A7 |
| 3 | C (A) | 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID | non-polymer | 241.3 | 1 | Chemie (ID8) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 13 - 355 (UniProt: P05543)
B: 357 - 395 (UniProt: P05543)
| PDB | External Database | Details |
|---|---|---|
| Gly 346 | Ala 366 | engineered mutation |
| Ala 347 | Val 367 | engineered mutation |
| Met 348 | Pro 368 | engineered mutation |
| Phe 349 | Glu 369 | engineered mutation |
| Leu 350 | Val 370 | engineered mutation |
| Ala 352 | Leu 372 | engineered mutation |
| Ile 353 | Ser 373 | engineered mutation |
| Pro 354 | Asp 374 | engineered mutation |
| Arg 355 | Gln 375 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43004.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 241.3 | |
| All* | Total formula weight | 43245.7 |
