2XM9
Structure of a small molecule inhibitor with the kinase domain of Chk2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | SERINE/THREONINE-PROTEIN KINASE CHK2 | polymer | 329 | 37111.8 | 1 | UniProt (O96017) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | CDS1, CHECKPOINT KINASE 2 |
2 | A | 4-(1H-pyrazol-5-yl)-2-{4-[(3S)-pyrrolidin-3-ylamino]quinazolin-2-yl}phenol | non-polymer | 372.4 | 1 | Chemie (LWH) | |||
3 | A | NITRATE ION | non-polymer | 62.0 | 1 | Chemie (NO3) | |||
4 | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 210 - 531 (UniProt: O96017)
PDB | External Database | Details |
---|---|---|
Gly 203 | - | expression tag |
Pro 204 | - | expression tag |
Leu 205 | - | expression tag |
Gly 206 | - | expression tag |
Ser 207 | - | expression tag |
His 208 | - | expression tag |
Met 209 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37111.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 434.4 | |
All* | Total formula weight | 37546.3 |