2XM9

Structure of a small molecule inhibitor with the kinase domain of Chk2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE LWH A 1513

Chain	Residue
A	LEU226
A	GLY307
A	GLU308
A	GLU351
A	ASN352
A	LEU354
A	THR367
A	ASP368
A	HOH2153
A	SER228
A	LYS249
A	GLU273
A	ILE286
A	LEU301
A	GLU302
A	LEU303
A	MET304

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 A 1514

Chain	Residue
A	LEU375
A	GLY403
A	TYR404
A	ASN405
A	ARG406

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpeNVLL

Chain	Residue	Details
A	ILE343-LEU355

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Region: {"description":"T-loop/activation segment"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"18644861","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"11390408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17715138","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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